Oxymatrine Inhibits Bocavirus MVC Replication, Reduces Viral Gene Expression and Decreases Apoptosis Induced by Viral Infection
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منابع مشابه
Autophagy inhibits viral genome replication and gene expression stages in West Nile virus infection.
Autophagy is a lysosomal degradation pathway that is implicated in many viral infections. However, its role in West Nile virus (WNV) infection remains controversial. In the present study, we examined the relationship between WNV infection and autophagy in infected cells. We demonstrated that LC3-II expression, a molecular marker for autophagosomal membranes, was enhanced in WNV-infected cells 6...
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Acute or chronic viral infections can lead to generalized immunosuppression. Several mechanisms, such as immunopathology of CD8(+) T cells, inhibitory receptors, or regulatory T (Treg) cells, contribute to immune dysfunction. Moreover, patients with chronic viral infections usually do not respond to vaccination, a finding that has not been previously explained. Recently, we reported that CD169(...
متن کاملViral Infection and Apoptosis
Viruses are master molecular manipulators, and evolved to thrive and survive in all species.[...].
متن کاملBocavirus infection induces a DNA damage response that facilitates viral DNA replication and mediates cell death.
Minute virus of canines (MVC) is an autonomous parvovirus that replicates efficiently without helper viruses in Walter Reed/3873D (WRD) canine cells. We previously showed that MVC infection induces mitochondrion-mediated apoptosis and G(2)/M-phase arrest in infected WRD cells. However, the mechanism responsible for these effects has not been established. Here, we report that MVC infection trigg...
متن کاملIL-9 Inhibits Viral Replication in Coxsackievirus B3-Induced Myocarditis
Myocardial injuries in viral myocarditis (VMC) are caused by viral infection and related autoimmune disorders. Recent studies suggest that IL-9 mediated both antimicrobial immune and autoimmune responses in addition to allergic diseases. However, the role of IL-9 in viral infection and VMC remains controversial and uncertain. In this study, we infected Balb/c mice with Coxsackievirus B3 (CVB3),...
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ژورنال
عنوان ژورنال: Virologica Sinica
سال: 2019
ISSN: 1674-0769,1995-820X
DOI: 10.1007/s12250-019-00088-2